Abstract
It was investigated whether or not the release of cholecystokinin-like immunoreactivity from slices of rat caudatoputamen could be modulated via dopamine D 2-receptors. The release of immunoreactivity was stimulated by high concentrations of K + (35 to 55 mM). The effects of two D 2-selective dopaminergic agonists, RU 24926 and LY 141865, were tested on the K +-induced release. Both agents enhanced the release of immunoreactivity in a concentration-dependent manner. The effect of RU 24926 was blocked by (−)-sulpiride and domperidone, two selective D 2-antagonists. It is concluded that stimulation of dopamine receptors of the D 2-subtype enhances the release of cholecystokinin-like immunoreactivity from nerve endings in rat neostriatum.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
