Effects of secretin, cholecystokinin and caerulein on gastric secretion in response to sham feeding in dogs.

Abstract

AbstractSecretin (0.75–3.0 U/kg/h) did not regularly inhibit the acid secretory response to 10 min of sham feeding to a significant degree in 3 dogs with intact antrum. Cholecystokinin (0.75–5.0 U/kg/h) and caerulein (0.06–0.30 μ/kg/h) tended to increase acid output after sham feeding in these dogs. In antrectomized dogs the response to sham feeding was markedly enhanced by cholecystokinin (0.6–2.4 U/kg/h) and caerulein (0.06 μg/kg/h). Pepsin output after sham feeding was increased by secretin (3.0 U/kg/h) and tended to be reduced by cholecystokinin (3.0 U/kg/h) and caerulein (0.30 μg/kg/h). These findings indicate that gastric acid secretion in response to sham feeding is not inhibited by physiological amounts of secretin and in fact increased by cholecystokinin and caerulein. The pepsin output after sham feeding can be enhanced by secretin and possibly depressed by cholecystokinin. The physiological significance of these effects on pepsin secretion remains to be determined.