Abstract
Objective To investigate the effects of seawater immersion on wound inflammation and healing following Ⅱ -degree scald in rats. Methods One hundred and twenty male Wistar rats with 10％ total body surface Ⅱ -degree scald were randomly divided into the scald group (group A) and the scald plus seawater immersion group ( group B). Rats in group B were immersed in seawater for 4 hours, soon after they were scalded. Wound infection, the time of healing and changes in histopathology were closely observed. Levels of serum interleukin- 6 ( IL- 6 ) and tumor necrosis factor ( TNF- α ) were determined with enzyme-linked immunosorbent assay (ELISA). Results Levels of serum IL- 6 (320. 5 ± 28.5 ) pg/ml and TNF-α content ( 130.4 ± 17.3 ) pg/ml in group B increased significantly, when they were compared with those of group A (P ＜0. 05 ). Moreover, wound surface was seriously infected and wound healing time prolonged (P ＜ 0. 05 ). Biological culture showed that seawater immersion could promote bacteria growth. Pathological examination indicated that seawater immersion could aggravate wound swelling and inflammatory response of the injured tissue, and inhibit epithelialization and differentiation of various epidermal layers. Conclusions Scald coupled with seawater immersion could aggravate inflammatory response of the wound surface and inhibit wound healing in rats. Key words: Burn; Seawater immersion ; TNF- t; IL-6 ; Wound healing
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