Abstract
AbstractThe effects of scopoletin, a coumarin isolated from the fruit of Tetrapleura tetraptera Taub (Mimosaceae), have been investigated on the electrically-induced contractions, relaxations and twitches of some cholinergically- and adrenergically-innervated muscle preparations in vitro and in vivo. Scopoletin depressed or abolished electrically-evoked contractions of the chick oesophagus, rabbit duodenum and guinea-pig vas deferens in vitro. The coumarin also reduced or abolished the indirect electrically-evoked twitches of the rat isolated hemidiaphragm muscle preparation, or the contractions of the cat nictitating membrane induced by pre-ganglionic cervical sympathetic nerve electrical stimulation in vivo. Furthermore, scopoletin prevented or reversed the high frequency electrical stimulation-evoked relaxations of the rabbit isolated duodenum. These results were taken to imply blockade of neurotransmitters by scopoletin at the cholinergic and adrenergic neuro-effector junctions, neuromuscular junction...
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