Effects of Schisandra Chinensis baill lignans on learning and memory dysfunctions

Abstract

Step-down test, step-though test and Morris water maze were used to observe effects of SCL on learning and memory dysfunctions in mice; Spectrophometry was used to detect effects of SCL on AChE activities in serum and brain of mice. Compared with those of control group: latencies of HSCL group in memory were prolonged significantly and NOEs in learning and memory decreased significantly, latencies of MSCL group both in memory and in learning were prolonged significantly, and NOEs in memory decreased significantly; latencies of HSCL and MSCL groups were prolonged significantly and NOEs decreased significantly; latencies of HSCL and MSCL groups were prolonged significantly and NOEs decreased significantly; AChE activities in brain tissue and serum of mice with acquired memory dysfunction in HSCL, MSCL LSCL groups decreased significantly. SCL could improve learning and memory dysfunctions through lowering AChE activities.