Abstract
It is known that 5-hydroxytriptamine (5-HT)2A receptors have some roles in vascular constriction, platelet aggregation, and superoxide production by neutrophils. 5-HT2A receptor antagonists are therefore expected to be effective for sepsis. The present study was performed to investigate the effects of sarpogrelate, a 5-HT2A receptor antagonist on endotoxin shock in rats.
Highlights
Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide
This study shows that the inhibition of the intramyocardial expression of tumour necrosis factor (TNF)-α and of its secondary mediator COX-2 related to moderate hypothermia during cardiopulmonary bypass (CPB) is associated with the inhibition of p38 mitogen-activated protein kinase (MAPK)–acute pancreatitis (AP)-1, but not of the NF-κB pathway
Nominal values of inducible nitric oxide synthase (iNOS) detected by immunoassay were based upon calibration with commercial murine iNOS standards
Summary
Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide. Methods Eighty-one consecutive patients (age 63 ± 16 years, male n = 51, SAPS 2 score 49 ± 11, mechanical ventilation n = 50, vasopressors n = 56, renal failure n = 19, postoperative n = 23) admitted to the ICU during a 3-month period were evaluated. Probiotics administration was suggested to reduce the incidence of infections and the overall morbidity and mortality in surgical patients The aim of this prospective randomized clinical trial was to assess the effects of a combination formula of probiotics and prebiotics (Synbiotic 2000Forte; Medifarm, Sweden) versus prebiotics only (fiber) in critically ill, long-term mechanically ventilated trauma patients. This study examines the acute patient outcomes associated with the evolution of early total care to damage control orthopaedics for multiply injured patients with femoral shaft fractures
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