Abstract
Sanguis draconis, a resin known to improve blood circulation, relieve pain, stimulate tissue regeneration, and heal wounds, is widely used in clinical practice. In this study, we prepared an ethanol extract of sanguis draconis (EESD) containing 75.08 mg/g of dracorhodin. The experiment was carried out on 20 rats that were divided into two groups, a control group (n = 10) and an EESD group (n = 10). All the rats underwent a perforator flap surgery, after which post-operative abdominal compressions of EESD were given to the EESD group for seven days, while the control group received saline. Flap survival percentages were determined after seven days, and were found to be significantly higher in the EESD group than in the control group. Results of laser Doppler flowmetry (LDF) showed that perforator flaps in the EESD group had higher perfusion values than those of the control group. The flap tissues were stained with hematoxylin and eosin, followed by immunohistochemical evaluation. Superoxide dismutase (SOD) expression and micro-vessel development markedly increased in the EESD group, while malondialdehyde (MDA) levels decreased. This is the first study to investigate the effect of sanguis draconis on perforator flap survival. Our results demonstrate that sanguis draconis can improve perforator flap survival in rats by promoting microvessel regeneration and blood perfusion.
Highlights
Perforator flaps were first described by Koshima in 1989, and began to be widely used for the reconstruction of soft tissue defects when plastic surgeons recognized their usefulness as freestyle island flaps [1,2]
The content of dracorhodin in sanguis draconis was stipulated by the Chinese pharmacopoeia The content of dracorhodin in sanguis draconis was stipulated by the Chinese pharmacopoeia as to be 10 mg/g; its content in ethanol extract of sanguis draconis (EESD) should not be less than 65.65 mg/g according to the extraction as to be 10 mg/g; its content in EESD should not be less than 65.65 mg/g according to the extraction rate. rate
Ischemia and necrosis occur in distal flaps distal due toblood inadequate supply, leading to ischemia/reperfusion injury and venous due toflaps inadequate supply,blood leading to ischemia/reperfusion injury and venous congestion
Summary
Perforator flaps were first described by Koshima in 1989, and began to be widely used for the reconstruction of soft tissue defects when plastic surgeons recognized their usefulness as freestyle island flaps [1,2]. Various perforator flaps with versatile designs have been developed to replace the traditional flaps and reduce donor morbidity [3,4]. In sanguis draconis, wasdraconis reported to induce these studies indicate this resin and vascular endothelial growth factor (VEGF). Dracorhodin, the main component in sanguis has multiple pharmacological benefits that require further investigation. Theseon studies indicate that this resin hasthe multiple our knowledge, studies investigated its All effects perforator flaps, especially, effects on pharmacological benefits that require further investigation. Studies have investigated its effects on perforator flaps, especially, the effects on the blood perfusion of. We tested the hypothesis that an ethanol extract of sanguis draconis (EESD) could remote flaps. In. In this study, we tested the hypothesis that an ethanol extract of sanguis draconis (EESD). We investigate the effect of the administration route on the efficacy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
