Abstract
Background: Common sage (Salvia officinalis L., Lamiaceae) is an aromatic and medicinal plant well known for its antioxidant properties. This plant belongs to Lamiaceae family and has many pharmaceutical properties. Some in vivo studies have shown the biological antioxidant effects of sage. As a member of Salvia officinalis Labiatae, sage is also known as “Maryam flower” in Iran. Sage importance lies in its therapeutic potential. It has been exploited as an anti-spasmodic, astringent, sedative, anti-hyperglycemic, and anti-inflammatory agent in Iranian medicine. Objective: Studying the anticancer effects of the compounds in Salvia officinalis extracts, such as cineol and camphor. Methods: Cancer was induced by DMBA (dimethyl-benzantheracene) dissolved in sunflower oil for 4 weeks. The case group was treated with sage leaf hydroalcoholic extract for 4 weeks; while the controls received distilled water. Result: Angiogenesis is a key process in cancer spread and metastasis. The hydroalcoholic extract of garden sage halted angiogenesis in the breast cell line of both human and mouse models; the highest impact was observed in hexane extract. Findings indicated the therapeutic effects of garden sage (i.e. its in vitro anti-angiogenesis activity and anti-migratory properties). Conclusion: Saliva officinalis can potentially prevent breast cancer.
Highlights
Anti-Tumorigenic Effects of Salvia Officinalis Regarding the important role of protease enzymes in various complications including cancer, a possible way to combat such complications is the limited application of inhibitory molecules
The results were analyzed by SAS-2000 software using a factorial experiment based on a completely randomized design, and the least significant difference (LSD) mean comparison method at the probability level of 95%
Angiogenesis is a key process in cancer spread and metastasis
Summary
Anti-Tumorigenic Effects of Salvia Officinalis Regarding the important role of protease enzymes in various complications including cancer, a possible way to combat such complications is the limited application of inhibitory molecules. Jedina et al [1] extracted - urosolic from garden sage in 2006 to assess its behavior by means of in-vitro protease activity assay on serine protease (trypsin, urokinase) and cysteine protease. Their results indicated the inhibitory impact of - urosolic acid on all the tested proteases in micro molar concentrations. In 2010, Hadri et al [2] investigated the toxicity of garden sage essence on the cancerous cell lines. They extracted the essence through aqueous distillation, and its components were separated using column chromatography.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
