Abstract
Klotho was involved in sodium reabsorption and the regulation of blood pressure. Animal studies indicated Klotho deficiency could mediate the development of salt-sensitive hypertension, indicating its correlation with salt sensitivity. We aimed to explore the responses of Klotho to salt intake through dietary intervention in Chinese adults. Forty-four participants were enrolled from Lantian county of Shaanxi, China. All participants sequentially underwent a 3-day normal diet, a 7-day low-Na+ diet, and a 7-day high-Na+ diet. The concentrations of serum Klotho were assessed by using ELISA kits. Serum level of Klotho was 360.44±93.89pg/mL at baseline and increased while changed to low-salt diet (478.65±183.25 vs 360.44±93.89pg/mL, P<.001). During high-salt diet, serum Klotho decreased to 354.37±98.16pg/mL (P<.001, compared to low-salt diet). The overall responses of Klotho were more prominent in salt-resistant participants. Serum Klotho of salt-resistant group changed from 353.92±97.65pg/mL to 496.76±196.21pg/mL while changed from normal diet to low-salt diet (P<.001) and decreased to 350.37±99.50pg/mL during high-salt intake (P<.001). Furthermore, the response of serum Klotho to low-salt intervention was much greater in salt-resistant individuals than in salt-sensitive ones. The responses of serum Klotho to dietary salt intervention were influenced by salt sensitivity, which was more prominent in salt-resistant participants.
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