Abstract
Objective: To evaluate the effect of salbutamol, montelukast, and prednisone on orthodontic tooth movement in rats. Material and Methods: In vivo experimental preclinical study. The sample consisted of 48 rats randomly distributed in four study groups. Group A was given saline solution; to group B, salbutamol 4 mg/Kg; to group C, montelukast 2.5 mg/Kg and to group D, prednisone 2.5 mg/Kg. All were fitted with orthodontic devices and the medications were administered intraperitoneally every 12 hours for 5 days. The clinical evaluation (variation in the interincisal distance) was performed at one, three, five, and seven days and the histopathological analysis (cell count) at five and seven days. Results: In the clinical evaluation of the variation in the interincisal distance, a significant difference was found in all the evaluations (p <0.05). It was found that the salbutamol group presented higher variation values in the interincisal distance on all the days evaluated. In the histopathological analysis at five and seven days, it was found that the osteoblast and osteocyte count was significantly higher in the salbutamol group compared to the other groups (p ><0.05). However, in the subgroup analysis, it was found that there was no significant difference in the osteoblast and osteocyte count between the prednisone, montelukast, and control group (p>0.05). Conclusion: The administration of salbutamol increased the magnitude of orthodontic tooth movement; nonetheless, the administration of montelukast and prednisone did not modify the magnitude of orthodontic tooth movement in rats. Keywords Albuterol; Montelukast; Prednisone; Rats; Tooth movement.
Highlights
I n recent years, the number of patients requiring orthodontic treatment has increased, some of them with systemic diseases that need medication [1]
In the determination of the variation in the interincisal distance (VIID) of all the study groups, a significant difference was found during all the evaluations (p
In the post hoc analysis, significantly lower VIID values were found in the prednisone group at day one and significantly higher VIID values in the salbutamol group at three, five, and seven days compared to the control group (p
Summary
I n recent years, the number of patients requiring orthodontic treatment has increased, some of them with systemic diseases that need medication [1]. Pharmacotherapy of asthma includes drugs that could affect orthodontic tooth movement [5]. Some studies report that the adrenergic system can regulate bone remodeling through beta-2 receptors, inhibiting bone formation and increasing osteoclastogenesis in cell cultures [9,10]. In vitro studies have reported that leukotrienes can decrease osteoblast proliferation and activity while stimulating osteoclast formation and activity [11]. These findings suggest that antileukotrienes could modify bone remodeling
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
