Effects of S-8527 (1, 1-BIS [4’-(l”-Carboxy-L”-Methylpropoxy) Phenyl] Cyclohexane), A New Hypolipidemic Compound, on Platelet Aggregation, Adhesiveness and Blood Coagulation in Rats

Abstract

Effects of S-8527 (1, 1-bis [4’-(l”-carboxy-L”-methylpropoxy) phenyl] cyclohexane) on platelet aggregation, adhesiveness and blood coagulation were examined in rats. In animals maintained on a semisynthetic diet containing sucrose (62%) as the only carbohydrate source, platelet adhesiveness increased as compared with that in rats fed a normal chow pellet. Under these experimental conditions, oral dose of S-8527 (30–300 mg/kg) for 14 days decreased platelet adhesiveness and ADP-induced platelet aggregation, but did not decrease collagen-induced platelet aggregation. S-8527 also showed a slight but significant increase of R value of thrombelastograph. In rats which were fed a normal chow pellet oral dose of S-8527 for 14 days did not significantly affect the several tests of platelet function and blood coagulation. These results suggest that S-8527 normalizes the platelet function in a hyper-adhesive state, but does not affect the platelet function in a normal state.