Effects of Roux-en-Y gastric bypass on insulin secretion and sensitivity, glucose homeostasis, and diabetic control: A prospective cohort study in Chinese patients

Abstract

To report on the effects of Roux-en-Y gastric bypass operation for obesity on measures of adiposity, insulin secretion and sensitivity, glucose homeostasis, and improvement in diabetic control in Chinese patients. This was a prospective cohort study of 152 participants (81% with diabetes) who were recruited for bariatric operation. Mean body mass index was decreased by 18.1% from 30.31±5.38kg/m2 at baseline to 24.45±3.79kg/m2 at 2years (P<.001). Indices of insulin secretion, including serum c-peptide (both fasted and at various time points during an oral glucose tolerance test) improved at the 3-year follow-up, with a significant improvement in insulin sensitivity and glucose homeostasis. The effects of Roux-en-Y gastric bypass 3years postoperative on adiposity were paralleled by a significant improvement in insulin secretion and sensitivity, and glucose tolerance.