Abstract
Objective: The study aimed to determine the effect of rosemary (Rosmarinus officinalis L.) leaf extract on healing angular cheilitis induced byStaphylococcus aureus and Candida albicans in male Wistar rats.Methods: We assessed 24 male Wistar rats that were divided into four groups: The first group was induced by S. aureus and given rosemary leafextract, the second group was induced by S. aureus and given gentamicin, the third group was induced by C. albicans and given rosemary leaf extract,and the fourth group was induced by C. albicans and given miconazole. All rats in each group were treated, and wound length and erythema wereobserved for 7 days.Results: The average wound length on the 7th day was 0.00±0.0 mm in the first group, 0.29±0.4 mm in the second group, 0.00±0.0 mm in the thirdgroup, and 0.25±0.2 mm in the fourth group. Statistical analysis demonstrated significant differences in wound length for each treatment group.Conclusion: Rosemary leaf extract has a healing effect on angular cheilitis induced by S. aureus and C. albicans in male Wistar rats.
Highlights
Global “Back to Nature” trends have increased public awareness of organic food production and healthier, safer, and cheaper raw materials using natural ingredients [1]
Based on the results of the present study, rosemary leaf extract has a healing effect on angular cheilitis induced by S. aureus and C. albicans in male Wistar rats
Group 1, induced by S. aureus and given rosemary leaf extract, showed the fastest healing from angular cheilitis wounds. This is in agreement with Moreno et al who demonstrated that rosemary extract was an effective antibacterial agent against Gram-positive bacteria such as S. aureus
Summary
Global “Back to Nature” trends have increased public awareness of organic food production and healthier, safer, and cheaper raw materials using natural ingredients [1]. Various types of plants are extremely beneficial, as herbal medicines. Indonesia is the second most biodiverse country in the world, with approximately 30,000 species of plants, including approximately 2500 species with medicinal properties [1], demonstrating that Indonesia is an excellent source for plants that are useful as herbal medicines. One type of plant that is used as herbal medicine is an ornamental plant [2]. Rosemary (Rosmarinus officinalis L.) is a decorative plant and contains medicinal ingredients in the form of phytochemicals, such as flavonoids, phenolic acid, tannic acid, saponin, carnosic acid, borneol, and essential oils which are beneficial to human health [3,4].
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