Abstract
Rhubarb extract was given orally to rats with diabetic nephropathy induced by subtotal nephrectomy and injection of streptozotocin. As a result, high blood and urinary glucose levels, which were conspicuous in similarly treated rats that were not given rhubarb extract, were ameliorated. Furthermore, improvement of hyperlipidaemia, and accelerated excretion of urinary urea nitrogen and creatinine were observed. These findings indicate that rhubarb extract has potential as a new therapeutic agent for inhibiting the progression of diabetic nephropathy. © 1997 John Wiley & Sons, Ltd.
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