Abstract
Sprague-Dawley male rats with adequate storage of vitamin A were fed vitamin A deficient diet either alone (RA-) or supplemented with retinoic acid (RA+). The rats were sacrificed at different days for the measurement of free retinol and the composition of retinyl esters in liver. At the same time the plasma retinol levels of these rats were also determined. Supplementation of retinoic acid significantly lowered the plasma retinol levels with a concomitant slower depletion of the total vitamin A in the liver of RA+ rats as compared. to RA-rats. The ratio of retinyl esters to free retinol in the liver tissue of RA- rats decreased with time, whereas in RA+ rat livers the ratio remained constant. The percentage distribution of retinyl esters in the liver tissue revealed a significant decrease in saturated retinyl esters with an increase in unsaturated retinyl esters in the RA+ group compared to RA- group. These data support the earlier findings that retinoic acid spares the utilization of retinol and suggest that it may affect the release of retinol from retinyl esters in the liver.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
