Abstract
BackgroundResveratrol is a polyphenolic phytoalexin that has been shown to exhibit osteoprotective and chondroprotective properties. We examine the effects of resveratrol treatment on bone and cartilage tissue of obese, diabetic ob/ob mice.MethodsEight-week-old ob/ob and lean control mice were given trans-resveratrol at an oral dose of 25 mg/kg for 3 weeks. Histomorphometric and cross-sectional-geometric variables were analyzed.ResultsOb/ob mice in our study exhibit significantly reduced femoral length, resistance to loading, and tibial growth plate total area and calcified area than lean controls (P < 0.05). Resveratrol treatment significantly increased cortical area in both ob/ob and control mice, but did not improve cross-sectional indicators of resistance to bending. Resveratrol treatment also reduced tibial length and calcified growth plate cartilage area in comparison to untreated mice (P < 0.05).ConclusionResveratrol treatment of ob/ob mice had mixed effects on bone histomorphometry at the femoral midshaft. Treatment increased cortical area but decreased bone length.
Highlights
Obesity has been identified as an important risk factor in the development of disorders that affect bone health, including type 2 diabetes
The aim of this study is to investigate the effects of resveratrol treatment on bone and cartilage tissue of obese, diabetic ob/ob mice
In support of these findings, our study shows that ob/ob mice have shorter limb bones and reduced cortical area at the femoral midshaft than lean controls
Summary
Obesity has been identified as an important risk factor in the development of disorders that affect bone health, including type 2 diabetes. According to the World Health Organization, approximately 85% of individuals diagnosed with type 2 diabetes are obese. Type 2 diabetics have elevated rates of bone fracture, at sites characterized by the presence of abundant cortical bone, such as limb bones [1,2,3]. Diabetes-related loss of cortical bone, coupled with inadequate compensatory trabecular growth, may reduce resistance to bending loads and leads to increased incidence of bone fracture [4,5]. The relationship among obesity, bone health, and diabetes is extremely complex. We examine the effects of resveratrol treatment on bone and cartilage tissue of obese, diabetic ob/ob mice
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