Abstract
BackgroundStreptococcus mutans is the principal etiological agent of human dental caries. The major virulence factors of S. mutans are acid production, acid tolerance, extracellular polysaccharide (EPS) synthesis and biofilm formation. The aim of this study is to evaluate the effect of resveratrol, a natural compound, on virulence properties of S. mutans.ResultsResveratrol at sub-MIC levels significantly decreased acid production and acid tolerance, inhibited synthesis of water-soluble polysaccharide and water-insoluble polysaccharide, compromised biofilm formation. Related virulence gene expression (ldh, relA, gtfC, comDE) was down-regulated with increasing concentrations of resveratrol.ConclusionsResveratrol has an inhibitory effect on S. mutans cariogenic virulence properties and it represents a promising anticariogenic agent.
Highlights
Streptococcus mutans is the principal etiological agent of human dental caries
We focused on the effects of resveratrol on acid production, acid tolerance, extracellular polysaccharide synthesis, biofilm formation and structure, virulence gene expression
Growth curve assay and minimum inhibitory concentration (MIC) We evaluated the effects of resveratrol with different concentrations on growth rate of S. mutans by growth
Summary
Streptococcus mutans is the principal etiological agent of human dental caries. The major virulence factors of S. mutans are acid production, acid tolerance, extracellular polysaccharide (EPS) synthesis and biofilm formation. One of the most important virulence factors is its ability to produce glucosyltransferases (GTFs) to catalyze synthesis of extracellular polysaccharides (EPS) from. Fluoride plays an important role in preventing the prevalence and severity of dental caries [7]. It is a well-known cariostatic agent via the inhibition of demineralization and the enhancement of remineralization and the inhibition of bacterial activity such as acid production, acid tolerance and EPS formation [8]. The development of an alternative cariostatic agent with minimal side effects is urgent
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