Abstract
Resveratrol (Res) a natural phytoalexine has a wide range of beneficial effects including anti-inflammatory, anti-cancer, anti-aging and vasoprotective effects. We examined if Res reverses the aged-related increases in catecholamine biosynthetic enzyme levels in the adrenal medulla. Male F-344xBN rats were assigned to young control (YC - 6 mo), young Res-treated (YR - 6 mo), old control (OC - 24 mo) and old Res-treated (OR - 24 mo) groups. Res (15 mg/kg) was given to YR and OR rats in drinking water for 14 days, and expression of tyrosine hydroxylase (TH), dopamine-β hydroxylase (DβH) and neuropeptide Y (NPY) were examined in the adrenal medulla. TH and DβH mRNA expressions were significantly higher in the adrenal medulla of OC rats compared to YC (P<0.05), but Res treatment reversed the age-related up-regulation of these enzymes in OR group. NPY, which is co-released with catecholamines in the adrenal medulla and stimulates the synthesis of TH and DβH, was also up-regulated with age and down regulated in response to Res in the OR group. This data indicates that treatment with Res can reverse age-related changes in adrenomedullary catecholamine biosynthesis. Supported by Department of Veteran Affairs; Rehabilitation R&D, GRECC, Medical Research Services, National Institute of Aging, and American Heart Association.
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