Abstract
The aim of this study is to evaluate the effect of resveratrol nanocapsules (RV-NCs) by quantitative insulin sensitivity check index (QUICKI) for insulin resistance diagnosis on metabolic syndrome induction in mice. Next, the applicability of these nanocapsules (NCs) was evaluated in metabolic syndrome induced in 40 mice. RV-NCs were synthesized by interfacial deposition method and was analyzed by various methods including Zetasizer, high-performance liquid chromatograph, potentiometer and scanning electron microscopy. The analysis results show a zeta potential of − 7.15, loading efficiency of 99.54 ± 1.02% and particle size of 207 nm for RV-NC production. Collected data from mice examination were analyzed by ANOVA and Tukey criteria. The validity and the reproducibility of the QUICKI index in a population of mice were determined and found that is a significant difference between high fat diet group and the control group (p < 0.05). In addition, the result obtained by the Tukey test indicated the difference in insuline and glucose levels of these group. Also, it probably is associated with the increase in the in vivo stability, which is obtained by the effective formulation of nanocapsules for resveratrol delivery.
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