Effects of restrictive transfusion and positive transfusion on acute upper gastrointestinal hemorrhage

Abstract

Objective To study and compare the effects of restrictive transfusion and positive transfusion on acute upper gastrointestinal hemorrhage. Methods A total of 102 patients with acute upper gastrointestinal hemorrhage were enrolled and were divided into observation group and control group, according to random number table method, with 51 cases in each group. The control group was treated by positive transfusion strategies, and the observation group was treated by restrictive transfusion strategy; at the same time, the two groups underwent the routine hemostatic treatment. The total effective rate, bleeding time, antifebrile time, hemostasis rate, blood coagulation function index, risk score of recurrence of hemorrhage were compared between the two groups. Results Cure rate of observation group was higher than that of control group (P 0.05). The bleeding time, antifebrile time in observation group were shorter than those in control group (P 0.05). Prothrombin time (PT), thrombin time (TT), activated partial thrombin time (APTT) after blood transfusion were significantly reduced in the two groups (P<0.05); while after blood transfusion, PT, TT and APTT in observation group were significantly shorter than those in control group (P<0.05). Risk score of recurrence of bleeding in observation group (2.57±0.78) was significantly lower than that in control group (3.42±0.86), P<0.05. Conclusions Restrictive transfusion in the treatment of patients with acute upper gastrointestinal bleeding could expedite hemostasis, be conductive to alleviate symptoms, and reduce risk of recurrence of bleeding, and be helpful to improve the function of blood coagulation. Key words: Acute upper gastrointestinal bleeding; Restrictive transfusion; Positive transfusion