Abstract
Simple lifestyle changes can prevent or delay the onset of type 2 diabetes mellitus (T2DM). In addition to maintaining a physically active way of life, the diet has become one of the bases in managing TD2M. Due to many studies linking the ability of resistant starch (RS) to a substantial role in enhancing the nutritional quality of food and disease prevention, the challenge of incorporating RS into the diet and increasing its intake remains. Therefore, we conducted this review to assess the potential benefits of RS on metabolic biomarkers in pre-diabetes and diabetes adults based on available intervention studies over the last decade. Based on the conducted review, we observed that RS intake correlates directly to minimize possible effects through different mechanisms for better control of pre-diabetic and diabetic conditions. In most studies, significant changes were evident in the postprandial glucose and insulin incremental area under the curve (iAUC). Comparative evaluation of RS consumption and control groups also showed differences with inflammatory markers such as TNF-α, IL-1β, MCP-1, and E-selectin. Only RS2 and RS3 were extensively investigated and widely reported among the five reported RS types. However, a proper comparison and conclusion are deemed inappropriate considering the variations observed with the study duration, sample size, subjects and their metabolic conditions, intervention doses, and the intervention base products. In conclusion, this result provides interesting insights into the potential use of RS as part of a sustainable diet in diabetes management and should be further explored in terms of the mechanism involved.
Highlights
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to defective insulin secretion, action or both [1]
The search resulted in 50 articles produced with a refined search based on the availability of full text, peer-reviewed articles and library collection access
Three metabolic investigations: a two-step euglycemic–hyperinsulinemic clamp combined with an infusion of [6,6-2H2] glucose, a meal tolerance test (MTT) with arterio-venous sampling across the forearm, and whole-body imaging
Summary
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to defective insulin secretion, action or both [1]. Resistant Starch Interventions on Metabolic Biomarkers glucose tolerance (IGT)/2hPG in a 75 g OGTT of 7.8–11.0 mmol/L [5] or HbA1c of 6.0% to 6.4% [6], each of which places individuals at high risk of developing diabetes and its complications [7]. The study showed that T2DM continues to be the leading cause of human suffering and deaths as it continues to increase in prevalence and incidence. This phenomenon continues, and there are no sights for reduction despite efforts in clinical care, research and public health interventions [8]. Poor dietary control and a sedentary lifestyle contribute to higher BMI that further elevates the associated risks [9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
