Abstract
Objective To investigate the effects of intra-arterial chemotherapy on Bcl-2 and Bax expression in pancreatic cancers to seek new approaches for treatment of pancreatic cancer. Methods Apoptotic index (AI) was detected by terminal-deoxynucleotide transferase mediated d-UTP nick end labeling (TUNEL) and expression of Bcl-2 and Bax with immunohistochemistry in 10 cases of pancreatic cancer treated by intra-arterial chemotherapy (group A) and 32 cases without the treatment (group B). Results AI was significantly higher in group A than in group B (P<0.05). The expression of Bcl-2 was markedly decreased but that of Bax remarkably increased in group A as compared with group B (P<0.05). Conclusions Intra-arterial chemotherapy can upregulate apoptosis of pancreatic cancer cells.
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