Abstract
The effect of regional hypercalcemia on histamine-induced gastric acid secretion from chambered fundic segments was studied in five anesthetized mongrel dogs. This preparation allowed direct infusion of calcium into the nutrient artery of the gastric segment whereby venous effluent calcium levels were maintained in excess of 14 mg%, while systemic calcium levels were within a normal range. Blood flow, as measured by a venous effluent technique, did not change. Acid secretion decreased from 43.03 ± 7.13 to 12.20 ± 5.72 μEq/min during calcium infusion and rose to 37.04 ± 3.83 μEq/min when the infusion was terminated. These results provide clear evidence that calcium has a direct and reversible inhibitory effect on histamine-induced parietal cell secretion from exteriorized fundic segments of dog stomach.
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