Effects of Regional Arterial Infusion Chemotherapy Combined With Laparoscopic Resection on the Prognosis of Colorectal Cancer

Abstract

To explore the effect of regional arterial infusion chemotherapy combined with laparoscopic surgery on the prognosis of patients with colorectal cancer and the serum interleukin-8, insulin-like growth factor binding protein-3, blood vascular endothelial growth factor and E-cadherin. From January 2019 to January 2020, 122 cases of colorectal cancer patients who planned to undergo laparoscopic surgery in our hospital were selected as the research objects and the research objects were divided into observation group and control group according to the random principle, with 61 cases in each group and control group. The patients in the group received laparoscopic surgery and the patients in the observation group received regional arterial infusion chemotherapy before operation. The total incidence of complications after operation was compared between the two groups and the serum tumor marker levels before and after operation was compared between the two groups, including interleukin-8, E-cadherin, insulin-like growth factor binding protein-3 and vascular endothelial growth factor; 3 y after operation, the comparison survival rates of patients in the two groups. The total incidence of postoperative complications in the observation group was 8.20 %, the interleukin-8 level was 92.16±11.1 pg/ml, the positive rate of E-cadherin was 37.70 % and the insulin-like growth factor binding protein-3 level was 4.08±0.72 ng/ml. The overall incidence of complications in control group was 14.75 %, the interleukin-8 level was 93.08±11.54 ng/ml, the positive rate of E-cadherin was 34.43 % and the insulin-like growth factor binding protein-3 level was 4.11±0.74 ng/ml. There was no statistically significant difference between the two groups (p>0.05). The vascular endothelial growth factor level in the observation group was 129.54±16.98 pg/ml, which was significantly lower than that in the control group (192.72±17.25 pg/ml) and the difference was statistically significant (p<0.05). During the 3 y follow-up, the difference in survival rate between the two groups was statistically significant (p>0.05). Regional arterial infusion chemotherapy combined with laparoscopic resections is safe and feasible because it can reduce the vascular endothelial growth factor level in colorectal cancer patients and improve the 3 y survival rate of patients without increasing the incidence of surgical complications and inflammation.