Abstract
BackgroundAdditional studies comparing several reconstruction methods after proximal gastrectomy have been published; of note, it is necessary to update systematic reviews and meta-analysis from the current evidence-based literature.AimTo expand the current knowledge on feasibility and safety, and also to analyze postoperative outcomes of several reconstructive techniques after proximal gastrectomy.MethodsPubMed, Google Scholar, and Medline databases were searched for original studies, and relevant literature published between the years 1966 and 2019 concerning various reconstructive techniques on proximal gastrectomy were selected. The postoperative outcomes and complications of the reconstructive techniques were assessed. Meta-analyses were performed using Rev-Man 5.0. A total of 29 studies investigating postoperative outcomes of double tract reconstruction, jejunal pouch interposition, jejunal interposition, esophagogastrostomy, and double flap reconstruction were finally selected in the quantitative analysis.ResultPooled incidences of reflux esophagitis for double tract reconstruction, jejunal pouch interposition, jejunal interposition esophagogastrostomy, and double flap reconstruction were 8.6%, 13.8%, 13.8%, 19.3%, and 8.9% respectively. Meta-analysis showed a decreased length of hospital in the JI group as compared to the JPI group (heterogeneity: Chi2 = 1.34, df = 1 (P = 0.25); I2 = 26%, test for overall effect: Z = 2.22 (P = 0.03). There was also a significant difference between JI and EG in length of hospital stay with heterogeneity: Chi2 = 1.40, df = 3 (P = 0.71); I2 = 0%, test for overall effect: Z = 5.04 (P < 0.00001). Operative time was less in the EG group as compared to the JI group (heterogeneity: Chi2 = 31.09, df = 5 (P < 0.00001); I2 = 84%, test for overall effect: Z = 32.35 (P < 0.00001).ConclusionAlthough current reconstructive techniques present excellent anti-reflux efficacy, the optimal reconstructive method remains to be determined. The double flap reconstruction proved to lower the rate of complication, but the DTR, JI, JPI, and EG groups showed higher incidence of complications in anastomotic leakage, anastomotic stricture, and residual food. In the meta-analysis result, the complications between the JI, JPI, and EG were comparable but the EG group showed to have better postoperative outcomes concerning the operative time, blood loss, and length of hospital stay.
Highlights
Additional studies comparing several reconstruction methods after proximal gastrectomy have been published; of note, it is necessary to update systematic reviews and meta-analysis from the current evidence-based literature
The double flap reconstruction proved to lower the rate of complication, but the double-tract reconstruction (DTR), jejunal interposition (JI), jejunal pouch interposition (JPI), and EG groups showed higher incidence of complications in anastomotic leakage, anastomotic stricture, and residual food
If the rate of reflux esophagitis and anastomotic stricture after proximal gastrectomy can be reduced to that of total gastrectomy, proximal gastrectomy may become an advantageous treatment of choice for proximal Early gastric cancer (EGC) [45]
Summary
Additional studies comparing several reconstruction methods after proximal gastrectomy have been published; of note, it is necessary to update systematic reviews and meta-analysis from the current evidence-based literature. Gastric malignancy is one of the established malignancies associated with high incidence of mortality worldwide. Recent articles have reported the modern diagnostic and treatment methods on eradication of Helicobacter pylori to have a direct link on the decline in gastric cancer [1–3]. Gastric cancer rates have dwindled in diagnosis across the world but lamentably, it remains to be a conundrum in the surgical field [4, 5]. Cancer-related death rate for proximal gastric cancer (PGC) is higher compared to cancers at other sites of the stomach [9–11]. Several methods tested the sole therapeutic agent deemed reliable as a medicinal procedure of gastric cancer remains to be surgical resection. Despite the fact that there is no general agreement on a preference of procedures as a remedy for PGC [12], there is still no consensus on the choice of surgical procedures for PGC
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