Effects of recombinant human thyrotropin administration on 24-hour arterial pressure in female undergoing evaluation for differentiated thyroid cancer.

Gianna Rentziou,Katerina Saltiki,Maria Alevizaki,Anastasia Vemmou,Emily Mantzou,Nikolaos Zakopoulos,Kimon Stamatelopoulos,Efstathios Manios,Eleni Koroboki

doi:10.1155/2014/270213

Abstract

Objective. Thyroid-stimulating-hormone (TSH) receptors are expressed in endothelial cells. We investigated whether elevated TSH levels after acute recombinant TSH (rhTSH) administration may result in alterations in blood pressure (BP) in premenopausal women with well-differentiated thyroid carcinoma (DTC). Designs. Thirty euthyroid DTC female patients were evaluated by rhTSH stimulation test (mean age 40.4 ± 8.6 years). A 24 h ambulatory systolic and diastolic blood pressure (SBP, DBP) monitoring (24 hr ABPM) was performed on days 2-3(D2-3). TSH was measured on day 1(D1), day 3(D3), and day 5(D5). Central blood pressure was evaluated on D3. Twenty-three patients were studied 1–4 weeks earlier (basal measurements). Results. TSH levels were D1: median 0.2 mU/L, D3: median 115.0 mU/L, and D5: median 14.6 mU/L. There were no significant associations between TSH on D1 and D3 and any BP measurements. Median D5 office-SBP and 24 h SBP, DBP, and central SBP were correlated with D5-TSH (P < 0.04). In those where a basal 24 h ABPM had been performed median pulse pressure was higher after rhTSH-test (P = 0.02). Conclusions. TSH, when acutely elevated, may slightly increase SBP, DBP, and central SBP. This agrees with previous reports showing positive associations of BP with TSH.

Highlights

It is well known that thyroid hormones influence cardiovascular function and may modulate the vascular response, the endothelial function, and the arterial blood pressure [1]
The aim of our study was to investigate whether elevated thyroid stimulating hormone (TSH) levels after acute recombinant human TSH (rhTSH) administration may result in alterations in blood pressure in a 24-hour ambulatory blood pressure monitoring (ABPM) as well as in central arterial pressure in individuals who had undergone thyroid ablation with radioactive iodine for well differentiated thyroid carcinoma and who have in the reevaluation remission of disease
In our study we examined whether elevated TSH levels after acute rhTSH administration may result in alterations in arterial blood pressure, both peripheral and central, in differentiated thyroid carcinoma (DTC) patients without residual disease

Summary

Introduction

It is well known that thyroid hormones influence cardiovascular function and may modulate the vascular response, the endothelial function, and the arterial blood pressure [1]. It has been shown that thyroid stimulating hormone (TSH) levels even within the normal range are positively associated with systolic and diastolic blood pressure [4, 5]. This may suggest a direct action of TSH on the cardiovascular system especially as extrathyroidal actions of TSH have been reported [6]. In vitro studies have shown that TSH may alter the production of various vascular factors [9].

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Discussion

Conclusion