Abstract
BackgroundBased on the sample of obese children with relative growth hormone deficiency (GHD), the objective of our study was to determine the effects of rhGH treatment on cardiovascular risk factors, including body mass index (BMI), lipid levels and glucose metabolism index.MethodsA total of 43 obese children with relative GHD were included in our final analysis. The obese subjects were divided into two groups: recombinant human growth hormone (rhGH) treatment group and untreated control group.ResultsAfter 6 months, subjects in the rhGH treatment group had significant reductions in BMI standard deviation scores (SDS) compared with controls (2.32 ± 0.85 vs. 2.80 ± 0.61; P = 0.041), and Insulin-like growth factor 1(IGF-1) level increased during rhGH treatment, in comparison with the control group (702.91 ± 246.03 vs. 348.30 ± 131.93 ng/mL, P < 0.001). GH treatment reduced low density lipoprotein cholesterol (LDL-C) (2.20 ± 0.45 vs. 2.63 ± 0.76 mmol/L, P = 0.027), aspartate aminotransferase (AST) (21.26 ± 5.72 vs. 32.30 ± 17.68 mmol/L, P = 0.006) as well as alanine aminotransferase (ALT) (16.70 ± 6.72 vs. 45.20 ± 46.62 mmol/L, P = 0.002), and increased high density lipoprotein cholesterol (HDL-C) (1.45 ± 0.40 vs. 1.19 ± 0.23 mmol/L, P = 0.016) levels compared with the control group.ConclusionRhGH treatment for 6 months on obese children with relative GHD reduces BMI SDS, stabilize IGF-1 levels, and exerts beneficial effects on blood lipid profiles and live enzyme compared with untreated control group. Moreover, GH administration has no significant effects on increased insulin resistance and no adversely effect on glucose homeostasis.
Highlights
Based on the sample of obese children with relative growth hormone deficiency (GHD), the objective of our study was to determine the effects of recombinant human growth hormone (rhGH) treatment on cardiovascular risk factors, including body mass index (BMI), lipid levels and glucose metabolism index
At the 6-month visit, Insulin-like growth factor 1 (IGF-1) level increased during rhGH treatment, in comparison with the control group (702.91 ± 246.03 vs. 348.3 ± 131.93 ng/mL, P < 0. 001) (Table 3, Fig. 2b)
In the study, we conducted a set of experiments based on samples of obese children with relative GHD, we found that after 6 months of rhGH treatment compared with the untreated control group, there was a significant reduction in BMI standard deviation scores (SDS)
Summary
Based on the sample of obese children with relative growth hormone deficiency (GHD), the objective of our study was to determine the effects of rhGH treatment on cardiovascular risk factors, including body mass index (BMI), lipid levels and glucose metabolism index. Liang et al Lipids in Health and Disease (2018) 17:66 complications, and it presented a possible research direction for a forthcoming therapeutic approach for obesity-related metabolic and cardiovascular complications. In 2008, Utz et al [6] firstly proposed the concept of relative GHD syndrome in overweight and obese women without organic pituitary or hypothalamic disease, and found the inverse associations between the relative GHD syndrome and cardiovascular risk markers. Other studies have confirmed that a negative association exsits between GH secretion and cardiovascular risk factors in obese patients with normal pituitary function [8,9,10]
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