Abstract
Human serum albumin (HSA) is widely utilized in human culture medium to support embryo development for its capacity to carry growth-promoting factors, act as an antioxidant and is a highly stable, non-immunogenic compound. However, HSA is accompanied with risk of disease transmission, and is chemically undefined making it difficult to investigate culture conditions. We examined the effect of two recombinant HSA (rHSA), Optibumin® (InVitria) and Recombumin® (Albumedix), and compared its effects on mouse embryo development and human blastocyst extended culture with undefined HSA-SOLUTION™ (Vitrolife).
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