Abstract
Solid fuel combustion is an important source of the release of rare earth elements (REEs) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pressure change. A total of 24 rats were administered with 14 REE chlorides at four doses (six rats per group). Fur samples were collected both before and after administration. Blood samples were collected after 12 weeks of REE intake. The REE concentrations in rat fur and blood samples were measured by inductively coupled plasma mass spectrometry. For each week, blood pressure, as well as heart rate and pulse pressure, were measured. The linear mixed-effect model was used to analyze the relationship between REE administration dose and blood pressure change. We found that the REE concentration in fur, but not blood, samples exhibited significant dose–response relationships with administration dose. It suggested that hair samples are a more efficient matrix for indicating the exposure level of a population to REEs than blood samples. However, there was no dose–response relationships between the administration dose and blood pressure change of rats, or with heart rate and pulse pressure for the 14 REEs. We also did not find a dose–response relationship between REE administration levels and plasma concentration of 8-hydroxy-2’-deoxyguanosine, as an important DNA oxidative stress damage biomarker. In conclusion, hair samples are more suitable as a sample type to reliably assess exposure to REEs than blood samples, and REEs did not have a direct adverse effect on blood pressure in our rat model.
Highlights
Introduction distributed under the terms andRare earth elements (REEs) include 17 elements in the lanthanide series, which have similar physicochemical properties
It suggests that rare earth elements (REEs) administration did not significantly affect the body weight of rats in the REE administration groups
We firstly evaluated the effect of high doses of REE administration on blood pressure using a rat model, and found that REE exposure may not have a significant effect on changes in blood pressure
Summary
Rare earth elements (REEs) include 17 elements in the lanthanide series, which have similar physicochemical properties. It has been reported that there is positive association between indoor air pollution from coal combustion and concentrations of REEs in hair among women living in Shanxi Province, China [8]. The biological effects of REEs have been widely reported It seems that REEs have a “hormetic effect” with respect to their dose–response phenomenon, producing health benefits at low concentrations while causing damage at high intake. REE concentrations in hair and blood samples have both been described as reliable sample types for representing REE intake in the general population [9,11,20,21]. In our study, using a rat model, we aimed to: (1) screen the reliable exposure biomarkers of REEs, and (2) examine the effects of REE intake on blood pressure
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