Abstract
Introduction: Serum amyloid-A (SAA) and protein carbonyl group are rigorously related with cardiovascular diseases (CVDs) as a sensitive marker of an acute inflammatory state and as an important index of oxidative stress, respectively. Moreover, diet is one of the main factors that can modify cardiovascular risks. Therefore, this study aimed to investigate the effects of Ramadan fasting on SAA and protein carbonyl group levels in patients with CVDs. Methods: Twenty-one patients (21 male; mean age 52±9 years old) with CVDs (coronary artery disease, cerebrovascular, or peripheral arterial diseases) were participated in this study. Biochemical parameters were measured in patients 2 days before and 2 days after Ramadan fasting. SAA levels were assessed using enzyme-linked immunosorbent assay and Cayman’s protein carbonyl colorimetric assay was provided for measuring protein carbonyl groups. Results: According to the findings of the study, post-Ramadan levels of inflammatory biomarker, SAA was decreased significantly in patients with CVDs in comparison with the baseline before-fasting values (16.84±8.20 vs. 24.40±6.72 μg/ml, P = 0.021). In addition, Ramadan fasting significantly reduced the levels of protein carbonyl group in patients as compared with those of baseline values (33.08±15.31 vs. 43.65±16.88 nmol/ml, P = 0.039). Conclusion: Ramadan fasting has impressive effects on modulating CVDs by decreasing inflammation and oxidative stress markers. However, to get a clear conclusion with more results, further investigation is warranted.
Highlights
Serum amyloid-A (SAA) and protein carbonyl group are rigorously related with cardiovascular diseases (CVDs) as a sensitive marker of an acute inflammatory state and as an important index of oxidative stress, respectively
Significant decrease in SAA levels after Ramadan fasting This study evaluated the effects of Ramadan fasting on SAA levels as an acute-phase inflammatory protein and useful factor in cardiovascular risk prediction
We investigated, for the first time, the effects of Ramadan fasting on endothelial function in CVDs.[14]
Summary
Serum amyloid-A (SAA) and protein carbonyl group are rigorously related with cardiovascular diseases (CVDs) as a sensitive marker of an acute inflammatory state and as an important index of oxidative stress, respectively. Results: According to the findings of the study, post-Ramadan levels of inflammatory biomarker, SAA was decreased significantly in patients with CVDs in comparison with the baseline beforefasting values (16.84±8.20 vs 24.40±6.72 μg/ml, P = 0.021). Ramadan fasting significantly reduced the levels of protein carbonyl group in patients as compared with those of baseline values (33.08±15.31 vs 43.65±16.88 nmol/ml, P = 0.039). One of the main rituals of Islam, the religion worshiped by more than one billion people, is fasting during the holy month of Ramadan. In this month, Muslims abstain from eating and drinking from dawn to sunset. Previous studies showed that Ramadan fasting has an noticeable effect on blood pressure levels, lipid profiles, and other cardiovascular disease markers such as serum high sensitivity C-reactive protein (hs-CRP) and homocysteine.[2,3] The other studies conducted in Turkey and Albania have confirmed a major reduction in hospital admission rates for cardiovascular diseases during the Ramadan month.[4,5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
