Abstract

Objective To investigate the effects of radical resection of thyroid carcinoma combined with parathyroid autotransplantation (PAT) on postoperative parathyroid hormone, serum calcium and postoperative complications in thyroid carcinoma. Methods A retrospective analysis was performed on data of 86 cases undergoing total laparoscopic radical resection of thyroid carcinoma (control group) and 114 cases undergoing total laparoscopic radical resection of thyroid carcinoma and PAT (observation group) from November 2016 to November 2018. The clinical symptoms and signs were observed in the two groups on 1 d, 3 d, 7 d after operation. The levels of parathyroid hormone (PTH) and serum calcium were compared between the two groups on 1 d, 1 w, 4 w, 12 w, 24 w after operation. The occurrence of postoperative complications was evaluated in the two groups. Results On 1 d, 3 d, 7 d after operation, the incidences of sensory abnormality, finger/limb numbness, wrist- foot spasm, facial sign, Trousseau sign and anxiety in observation group were lower than those in control group (P<0.05). The levels of PTH and serum calcium in the two groups at 4 w, 12 w and 24 w after operation were significantly higher than those at 1 d after operation (P<0.05), and the above indexes in observation group at 4 w, 12 w, 24 w after operation were significantly higher than those in control group (P<0.05), and there were statistically significant differences in the between-group effects, time-point effects and interaction effects of between-group and time-point in the two groups (P<0.05). The incidences of postoperative hypocalcemia, temporary hypoparathyroidism (HP) and permanent HP were 0.05%, 13.16% and 0 respectively in observation group, which were significantly lower than 0.13%, 36.05% and 8.14% in control group (P<0.05). Conclusions Radical resection of thyroid carcinoma combined with PAT for thyroid carcinoma can significantly improve postoperative clinical symptoms and signs, significantly improve postoperative PTH level and low serum calcium, and reduce the risk of postoperative temporary HP and permanent HP. Key words: Thyroid carcinoma; Radical resection of thyroid carcinoma; Parathyroid autotransplantation

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