Abstract
Irradiation of a malignant tumor in a patient or in an experimental animal produces a variety of changes in the physiology, growth, and behavior of the neoplasm. Many of these changes are of significance in the therapy of human cancer, because they alter the sensitivity of the tumor to subsequent treatments with radiation or with other therapeutic modalities. A better understanding of the effects of radiation on tumors is therefore necessary in order that improved regimens may be developed in which therapy with radiation or radiation combined with other agents is delivered in a more optimum fashion. However, it is difficult to examine a subject of this complexity in the clinic, because severe technical problems and ethical considerations limit the observations that can be made and the phenomena that can be studied quantitatively. As a result, most of the available data defining the effects of radiation on tumors have been obtained from experiments with tumors in experimental animals or with experimental tumor models in vitro.
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