Abstract
Purpose: The articular cartilage exhibits a limited ability for self-healing in adult individuals. Gene therapy using rAAV vectors is a promising tool to treat cartilage lesions but the presence of neutralizing antibodies against AAV capsid elements in a majority of patients remains a limitation to the use of these vectors in the clinics. Carbon dots (CDs), a new class of nanocarriers capable of transferring plasmid DNA in several cell lines [1], may provide effective platforms to deliver rAAV as a means to overcome such a limitation.
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