Abstract

The purpose of this research is to clarify the protective effects of Notoginsenoside R1(R1)-Ginsenoside Rg1 (Rg1) on myocardial microcirculatory ischemia–reperfusion injury(I/R injury) in mice, and to investigate whether its myocardial protective effect mechanism is related to FUNDC1-mediated mitochondrial autophagy. The experimental study found that R1-Rg1 could improve cardiac function, reduce structural damage, restore myocardial barrier function, systolic and diastolic function in mice with myocardial I/R, with significant cardioprotective effects, and its mechanism of action may be related to NR4A1-CK2α-FUNDC1-mediated mitochondrial autophagy. This article will discuss some of the important findings of this study and explore the implications of these results for clinical practice and the treatment of MIRI.

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