Abstract
The effects of quinine on the peak amplitude and the decay of calcium currents (ICa) were investigated in nonidentified neurons isolated fromHelix pomatia. A concentration of 1×10−5−5×10−4 M quinine was found to produce a reversible dose-dependent deceleration in the decline of ICa ("lead" effect) and a reversible, slowly evolving dose-dependent reduction in ICa amplitude ("lag" effect). A reduction in amplitude down to half control level is observed at a quinine concentration of 6 ×10−5 M, while the current-voltage relationship of ICa shifts by 5–10 mV towards negative potentials. Results show that quinine successfully blocks calcium channels inHelix pomatia neurons.
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