Abstract
Paper description: Estrogen deficiency after ovariectomy induces an imbalance between the production of reactive oxygen species and the antioxidant defense system, leading to oxidative stress and resulting complications. Administration of either quercetin or vitamin E improved oxidative stress in ovariectomized rats. However, the coadministration of quercetin and vitamin E had a weaker improving effect than when either compound was applied alone. Ovariectomy-induced oxidative stress could be ameliorated by administration of either quercetin or vitamin E and could alleviate ovariectomy-induced dysfunction. Abstract: Estrogen deficiency after menopause accelerates redox imbalance, leading to oxidative stress (OS) and other postmenopausal complications such as osteoporosis and cardiovascular disease. In the present study, the effects of quercetin (Q), vitamin E (vitE) and estradiol (E2) on the oxidative status in ovariectomized (OVX) rats were investigated. OVX animals were treated with Q (15 mg/kg/day), vitE (60 mg/kg/day), E2 (10 µg/kg/day) and Q (7.5 mg/kg/day)+vitE (30 mg/kg/day) for 10 weeks. OS markers were analyzed in the serum and tibia of rats. Data indicated that after ovariectomy, rats exhibited a reduction in serum and tibia antioxidants and elevation of oxidant markers. The activities of antioxidant enzymes (AOEs), glutathione peroxidase (GPx), catalase (CAT) and glutathione reductase were decreased and the glutathione (GSH) content was reduced, whereas the malondialdehyde (MDA) level was increased. Treatment with Q, vitE and E2 markedly reversed these changes and improved OS. In conclusion, prevention by antioxidant agents, including Q and vitE, could be a potential approach in the management of menopause-related complications. https://doi.org/10.2298/ABS191115003V Received: November 15, 2019; Revised: December 15, 2019; Accepted: January 13, 2020; Published online: January 20, 2020 How to cite this article: Vakili S, Zal F, Mostafavipour Z, Savardashtaki A, Jafari Khorchani M, Hassanpour A. Effects of quercetin and vitamin E on ovariectomy-induced oxidative stress in ratserum and tibia. Arch Biol Sci. 2020;72(1):95-104.
Highlights
Menopause is defined by the final menstrual period and generally occurs when women are between 45 and 55 years of age [1]
Histograms with different letters are significantly different at P
A form of reproductive aging, is characterized by a complete failure of ovarian tissue to produce estrogen, which leads to an increase in oxidative stress (OS), bone loss, cardiovascular diseases (CVDs), neurologic and sexual disorders [34]
Summary
Menopause is defined by the final menstrual period and generally occurs when women are between 45 and 55 years of age [1]. Menopause is associated with different short-term consequences such as mood changes, vasomotor symptoms, urogenital difficulties, joint pains and long-term consequences, including osteoporosis, cardiovascular diseases (CVDs), neurologic disorders, sexual difficulties and metabolic dysfunction [1,2]. Estrogen deficiency has been reported to reduce antioxidant defenses and to increase the expression of some inflammatory cytokines [3]. Osteoporosis is one of the most common consequences of the menopause [2]. Bone homeostasis is Estrogen prescription as hormone replacement therapy (HRT) is the main choice to prevent the onset or to relieve postmenopausal symptoms [9]. Long-term HRT is associated with several adverse effects, such as increased risk of breast cancer, stroke, venous thromboembolism, cholecystitis and endo-
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