Effects of Qishenhuoxue granule in sepsis combined with myocardial injury

Abstract

Objective To research the effect of Qishenghuoxue granules in the treatment of sepsis combined with myocardial injury. Methods A total of 63 patients with sepsis combined with myocardial injury were randomly divided into two groups: 33 cases in control group (conventional therapy for 7 d) and 30 cases in observation group (Qishenhuoxue granule for 7 d). Thromboxane A2 (TXA2), prostaglandin I2 (PGI2), endothelin 1 (ET-1) and other cytokines were detected by enzyme-linked immunosorbent assay (ELISA). At the same time blood pressure, pulse, echocardiography were recorded. The mortality rate at the 28th day and the above values were statistically analyzed. Results On the 7th day after the intervention of Qishenhuoxue granule, N-terminal pro-brain natriuretic peptid (NT-proBNP) and troponin T (TNT) in the observation group and the control group were significantly lower than those on the 1st day, but there was no significant difference between the two groups at the same time point (P>0.05); On the 7th day after the intervention of Qishenhuoxue granule, the levels of angiotensin Ⅱ (Ang-Ⅱ) and ET-1 in the observation group were significantly lower than those in the control group (P<0.01), but there was no significant difference between the two groups in cardiac function index and 28 day mortality. Conclusions The Chinese herbal preparation Qishenhuoxue granule could reduce the blood levels of Ang-Ⅱ and ET-1, but its effect on improving myocardial injury is still worthy of further study. Key words: Sepsis; Cardiomyopathies; Qishenhuoxue granule; Cytokines