Abstract
We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/P1) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM rats and these effects were blocked by selective hepatic vagotomy. In contrast, in S5B/P1 rats fed an LF diet the responses to pyruvate and lactate were attenuated and were absent in S5B/P1 rats fed the HF diet. These data suggest that OM and S5B/P1 rats differ either in their metabolism of pyruvate and lactate or in their responses to these metabolites.
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