Abstract
Summary. COPD affects not only the respiratory system but has systemic effects including peripheral muscle dysfunction, synovial and vascular pathology and depression partly caused by the direct influence of inflammatory mediators. Pulmonary rehabilitation is recognized as a crucial component of management of patients with COPD. This study was performed in Research Institute of Pulmonology of Federal Medical and Biological Agency and evaluated one of rehabilitation methods, namely physical training, in term of its influence on systemic inflammation markers and level of testosterone in COPD patients. The study involved 31 patients with COPD stage III–IV treated with standard drug therapy according to the disease severity. Of them, 16 patients were involved in pulmonary rehabilitation programs. As a result, pulmonary rehabilitation group patients improved 6-min distance by 80 m, FEV1 by 13 % and decreased FRV by 14 % and RV by 30 % from baseline. These parameters did not change or changed non-significantly in patients treated with medications alone. Systemic inflammation and testosterone level were also improved in pulmonary rehabilitation group.
Highlights
vascular pathology and depression partly caused by the direct influence of inflammatory mediators
Pulmonary rehabilitation is recognized as a crucial component of man agement
This study was performed in Research Institute of Pulmonology
Summary
COPD affects the respiratory system but has systemic effects including peripheral muscle dysfunction, synovial and vascular pathology and depression partly caused by the direct influence of inflammatory mediators. В ФГУ "НИИ пульмонологии ФМБА России" было проведено ис следование, целью которого была оценка влияния одного из методов легочной реабилитации – физической тренировки – на маркеры системного воспаления и тестостерон у больных ХОБЛ. Изме нение показателей системного воспаления и тестостерона также было достоверным в группе пациентов с физической реабилитацией. Традиционные медикаментозные методы лечения больных хронической обструктивной болезнью лег ких (ХОБЛ) недостаточно эффективны для преодоле ния системных эффектов, включающих в себя пора жение периферической мускулатуры, синовиальных оболочек суставов, сосудов, а также депрессивные расстройства [1, 2]. Нами было проведено исследование, целью которого, была оценка влия ния методов физической реабилитации на маркеры системного воспаления и уровень тестостерона у па циентов с ХОБЛ
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