Abstract
The effects of various drugs on the distribution of 3H-dopamine in rat striatal synaptosomes were studied after superfusion with this radiolabelled neurotransmitter. By compartmental analysis of the efflux of radioactivity, drug effects on the total accumulation of 3H-dopamine, on the “bound fraction” and on the rate constant of the efflux of radioactivity from the tissue were determined. Subsequently, the synaptosomes were exposed to 40 mM K+, in order to assess also the effects of these drugs on depolarization-induced 3H-dopamine release.
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