Abstract
The effects of psychotropic drugs on hyperemotionality of the rat with lesions in the olfactory system, including the olfactory bulbs and olfactory tubercles (O.B.-O.T. rat), were investigated, and compared with the neurotoxic effects of these drugs measured on rotarod performance of the mice with bilateral olfactory bulb ablations (O.B. mice). Chlorpromazine, reserpine and meprobamate inhibited the hyperemotionality at doses close to their neurotoxic dose. Pentobarbital showed only a slight effect on the hyperemotionality at subhypnotic doses. Chlordiazepoxide, diazepam and haloperidol markedly inhibited the hyperemotionality at lower doses without causing neurotoxicity. Imipramine and amitriptyline selectively inhibited mouse-killing behavior (muricide) of the O.B.-O.T. rat without affecting the other hyperemotional responses to various stimuli, thus differing from tranquilizers. The mode of action of these drugs in the O.B.-O.T. rat was essentially the same as observed in either the O.B. and the septal rats. For evaluating the effects of psychotropic drugs, the O.B.-O.T. rats are superior to the O.B. and septal rats, as they share both offensive aggression of the O.B. rat and hyperreactivity of the septal rat, and furthermore they exhibited muricide in a much higher incidence soon after the brain lesions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
