Abstract
Aim of the study Psoralea corylifolia (PC) is a medicinal herb used to improve male reproductive function in Korean traditional medicine. It has been used for treatment of male infertility including sexual dysfunction by improving kidney function. Materials and methods To investigate the effect of PC on spermatogenesis, the cAMP-responsive element modulator (CREM) in rat testes was evaluated using sperm analysis, the reverse-transcription polymerase chain reaction, and Western blot analysis. PC was administered to 10-week-old male Wistar rats for 56 consecutive days, the sperm formation period of the rat. Results and conclusions The PC-treated rats had increased sperm counts with enhanced levels of CREM messenger RNA and protein, suggesting that PC induces spermatogenesis via CREM activation in rat testes.
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