Abstract
Vascular inflammation is an important factor which can promote diabetic complications. In the present study, we designed to examine the inhibitory effects of high glucose (HG)-induced vascular dysfunction by aqueous extract from Prunella vulgaris (APV) in HUVECs and HASMCs. We found that pretreatment with APV decreased HG-induced expression of CAMs, MMPs, and adhesion of HL-60 monocytic cells on HUVECs. A further analysis indicated that APV attenuated HG-induced translocation and transcription activity in p65 NF-κB signaling pathway. Pretreatment with APV significantly inhibited the formation of intracellular ROS. Additionally, APV-induced Akt phosphorylation could obviously increase not only the induced activation of HO-1 and eNOS but also transcription factor Nrf2. Further, in this study, [3H]-thymidine incorporation was significantly increased compared with control and this increase was decreased by APV. Migration and invasion assay also suggested an anti-proliferative effect of APV. This data cast a new light on the actions of Prunella vulgaris and its potential benefits to diabetic patients for preventing diabetic vascular complications.
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