Abstract
Knee osteoarthritis (KOA) and age are both associated with an increased risk of lower lean muscle mass (i.e., sarcopenia), which may lead to physical difficulty or functional limitation. Protein supplement (PS) combined with resistance exercise training (RET) improves body composition and strength gains in elder individuals. It remains unclear whether PS augments lean mass and strength gains of older patient with KOA undergoing RET. The purpose of this study is to identify the effect of PS plus RET on body composition and physical function in older women with KOA. Eligible female participants who are older than 55 years old and have a diagnosis of KOA are assigned to either experimental group (PS) or control group (placebo supplement). Both groups receive RET twice a week for a total of 12 weeks. Outcome measures includes analysis of body composition using bioelectrical impedance method, hand and leg strength, lower limb mobility (distance of functional forward reach, duration of single leg stance; timed sit-to-stand test, timed 10-m walk; timed up-and-go test, 30-s timed chair rise), physical activity using International Physical Activity Questionnaire and the Western Ontario and McMaster Universities Osteoarthritis Index score. All measures are tested before (baseline) and after RET (posttest). Analysis of covariance is also performed, using the pretest measures of both groups as the covariates, to test differences in post-test between the two groups. Sixteen patients in the experimental group (mean age 63.4 ± 7.6 y) and 16 in the control group (mean age 62.9 ± 8.7 y) completed the study. A statistically significant improvement of all measures was observed in both groups after intervention (all P < .05), and the experimental group exhibited a significantly superior improvement compared with the control group ( P < .05). Combing PS and RET exerted benefits on body composition, muscle strength, and physical capacity in older women with KOA.
Published Version
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