Abstract
Although we have found that protease-treated royal jelly (pRJ) benefit for the skeletal muscle mass and strength in the aged animals, the potential beneficial effects have not been evaluated in humans. The aim of this study was to determine whether pRJ intake had beneficial effects on muscle strength in elderly nursing home residents. One hundred and ninety-four subjects enrolled into this multicenter, randomized, double-blind, placebo-controlled study. Subjects received either placebo(Group 1), pRJ 1.2 g/d(Group 2), or 4.8 g/d(Group 3). Data through 1 year are reported for 163 subjects. The primary outcome measure is handgrip strength. Secondary outcomes include several physical performance tests (six-minute walk test, timed up and go test, and standing on one leg with eyes closed). The dropout rate was 16.0%. The means (95% confidence interval) of change in handgrip strength for placebo, low-dose, and high-dose groups are −0.98(−2.04,0.08), 0.50(−0.65,1.65) and 1.03(−0.37,2.44) kg (P = 0.06, P for trend = 0.02), respectively. No significant effects of the interventions were observed for physical performances. These findings suggest that pRJ treatment might not improve, but rather attenuate the progression of decrease in muscle strength in elderly people. In addition, we have not found that pRJ intervention can achieve improvement or attenuating the decrease in physical performance.
Highlights
We have found that protease-treated royal jelly benefit for the skeletal muscle mass and strength in the aged animals, the potential beneficial effects have not been evaluated in humans
We found that in vitro, Royal jelly (RJ) and protease-treated RJ increased the cell proliferation rate, promoted the cell differentiation, and activated Akt signaling pathway compared to controls in isolated satellite cells from aged mice; RJ and protease-treated royal jelly (pRJ) treatment increased the muscle weight, handgrip strength (Wire Hang Test), regenerating capacity of injured muscles, and serum insulin-like growth factor-1 (IGF-1) levels compared to controls in aged mice[16]
We based our study on previous animal research, which showed that dietary supplementation with RJ or pRJ may reduce declines in muscle mass and function in aged mice[16]
Summary
We have found that protease-treated royal jelly (pRJ) benefit for the skeletal muscle mass and strength in the aged animals, the potential beneficial effects have not been evaluated in humans. The aim of this study was to determine whether pRJ intake had beneficial effects on muscle strength in elderly nursing home residents. No significant effects of the interventions were observed for physical performances These findings suggest that pRJ treatment might not improve, but rather attenuate the progression of decrease in muscle strength in elderly people. Aging is associated with degenerative loss of skeletal muscle mass, quality and function[2, 3]. Age-related functional decline and decreases in the number of satellite cells contribute to loss of skeletal muscle mass and function in elderly population[8]. Sodium Phosphorus Iron Calcium Potassium Magnesium Copper Zinc Manganese Selenium Vitamins Thiamine Riboflavin Vitamin B6 α-tocopherol Folic acid Pantothenic acid Biotin Inositol Niacin Choline 10-Hydroxy-2-decenoic acid 10-Hydroxydecanoic acid
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