Effects of prostaglandin inhibition on renal function in deoxycorticosterone-acetate hypertensive Yucatan miniature swine

Abstract

This study evaluated the effect of prostaglandin (PG) on renal function in normal and deoxycorticosterone-acetate (DOCA) hypertensive Yucatan miniature swine. Eight animals were implanted with DOCA impregnated silicone strips. MAP increased in the conscious DOCA animals from a normal pressure of 110–115 mmHg, to 148 ± 4 mmHg.After 3–4 weeks, the DOCA hypertensive and eight normal (sham or non-implanted) animals were anesthetized with sodium pentobarbital which reduced MAP in the DOCA pigs to normotensive levels. Under anesthesia, PG inhibition (indomethacin or meclofenamate, 2 mg/kg i.v.) increased MAP only in the normal group (P < .05). PG inhibition caused a significant reduction in renal blood flow in both groups, but only decreased glomerular filtration rate in the DOCA animals (P < .05). Radioactive microsphere distribution to the outer cortex of the normal animals was significantly decreased with PG inhibition, (P < .05). No consistant changes in electrolyte excretion or urine flow rate was seen in either group following PG inhibition. These data indicate that PG may influence renal hemodynamics in both normal and DOCA hypertensive Yucatan miniature swine. The finding that PG inhibition selectively decreases GFR in the DOCA animals suggests a possible protective role of these hormones in this hypertensive animal model.