Effects of Propolis on Spatial Memory Induced by Lithium Pilocarpine in the Experimental Status Epilepticus Model in the Rats

Gülşen Kaya ,Memet Hanifi Emre

doi:10.7176/jnsr/9-18-01

Abstract

Status epilepticus (SE) is a common neurological disorder with repeated convulsions that persist for 30 minutes or longer in children and the elderly, leading to neuronal damage in the brain if it is not controlled. The lithium-pilocarpine (Li-Pc) model of SE is the most suitable and frequently used method for pathophysiological changes of SE. Keywords: Status epilepticus, propolis, spatial memory, hippocampus, Morris water maze. DOI : 10.7176/JNSR/9-18-01 Publication date :September 30 th 2019

Highlights

Epilepsy is a neurological disease characterized by spontaneous seizures caused by focal or generalized paroxysmal changes in neurological function by abnormal activity in the cortex
We are especially interested in status epilepticus. the status epilepticus is a special type of epilepsy which is characterized by a lasting seizure 30 minutes
The Effects of propolis on learning and spatial memory According to the results of this study, it was determined that propolis reduced the oxidative stress which increased the production of reactive oxygen species but it increased the protective mechanism of the neuronal cells, which is sensitive to the harmful effects of lithium-pilocarpine

Summary

Introduction

Epilepsy is a neurological disease characterized by spontaneous seizures caused by focal or generalized paroxysmal changes in neurological function by abnormal activity in the cortex. It affects approximately 1 % of the world population. Epilepsy is a serious neurologic disease and there are a lot of numbers type of seizures. The status epilepticus is a special type of epilepsy which is characterized by a lasting seizure 30 minutes. SE is a disease that must be diagnosed and treated quickly both because of being lifethreatening and causing serious neurological damage (Alverez –Croda et al 2016, Shinnar et al 1992)

Methods

Results

Discussion

Conclusion