Abstract
Background Pain aggravates the autonomic response to stress and raises neuroendocrine stress hormone levels. We compared the effects of propofol and sevoflurane on postoperative pain and neuroendocrine stress hormones. A prospective, randomized, and controlled trial was conducted with 60 patients. Methods We randomly allocated patients to groups P (remifentanil/propofol, n = 30) and S (remifentanil/sevoflurane, n = 30). Preoperative blood samples were taken to measure serum adrenocorticotropic hormone (ACTH), corticotropin-releasing hormone (CRH), glucagon, cortisol, aldosterone, and prostaglandin E2 (PGE2) levels. Intraoperatively and postoperatively, clinical parameters were monitored at different time points. The hormone levels were again measured in the follicular fluid and blood postoperatively. Result Demographic data were similar. The preoperative serum aldosterone levels were significantly higher in group P (p=0.001). Preoperative and postoperative serum ACTH, glucagon, cortisol, and PGE2 levels were significantly different in group P (p=0.009, p=0.004, p=0.029, and p=0.002); serum ACTH, glucagon, and PGE2 levels increased while serum cortisol levels decreased postoperatively. In group S, serum CRH and aldosterone levels, both increased in the postoperative period compared to the preoperative (p=0.001, p=0.006). Postoperatively, glucagon and PGE2 levels were both higher in group P than group S (p=0.019, p=0.015). In postoperative follicular fluid, glucagon and PGE2 levels were higher in group P, while cortisol levels were higher in group S (p=0.001, p=0.007, and p=0.001). Conclusion The effects of anesthetic agents were different. In group P, in the preoperative and postoperative evaluation, ACTH, glucagon, and PGE2 increased postoperatively, while cortisol decreased. In group S, aldosterone and CRH increased postoperatively. Glucagon and PG E2 were higher in group P than S, postoperatively.
Highlights
In vitro fertilization (IVF) techniques include the following steps [1]:(1) Ovarian stimulation: Medication is administered to the ovaries to produce eggs.(2) Egg collection: Ultrasoundguided transvaginal oocyte retrieval is performed to remove eggs from the woman’s body.(3) Fertilization: Top-quality eggs and sperm are stored in a suitable room. e sperm is placed into the eggs. is process is called fertilization.Pain Research and Management (4) Embryo culture: e fertilized egg is divided into an embryo.(5) Embryo transfer into the uterus: e embryo is inserted into the uterus 3–5 days after the follicular aspiration.Oocyte retrieval is a short procedure, usually lasting for 20 ± 30 minutes
We found no difference between the two groups in terms of age, body mass index (BMI), and operation time
Remifentanil requirements of the patients were higher in group P compared to group S (p < 0.001). ere was no statistically significant difference between the two groups in terms of postoperative visual analog scale (VAS) scores and postoperative analgesic requirements (Table 1)
Summary
In vitro fertilization (IVF) techniques include the following steps [1]:(1) Ovarian stimulation: Medication is administered to the ovaries to produce eggs.(2) Egg collection (follicular aspiration): Ultrasoundguided transvaginal oocyte retrieval is performed to remove eggs from the woman’s body.(3) Fertilization: Top-quality eggs and sperm are stored in a suitable room. e sperm is placed into the eggs. is process is called fertilization.Pain Research and Management (4) Embryo culture: e fertilized egg is divided into an embryo.(5) Embryo transfer into the uterus: e embryo is inserted into the uterus 3–5 days after the follicular aspiration.Oocyte retrieval is a short procedure, usually lasting for 20 ± 30 minutes. Pain Research and Management (4) Embryo culture: e fertilized egg is divided into an embryo. We compared the effects of propofol and sevoflurane on postoperative pain and neuroendocrine stress hormones. E hormone levels were again measured in the follicular fluid and blood postoperatively. E preoperative serum aldosterone levels were significantly higher in group P (p 0.001). In group S, serum CRH and aldosterone levels, both increased in the postoperative period compared to the preoperative (p 0.001, p 0.006). Glucagon and PGE2 levels were both higher in group P than group S (p 0.019, p 0.015). Glucagon and PGE2 levels were higher in group P, while cortisol levels were higher in group S (p 0.001, p 0.007, and p 0.001). In group P, in the preoperative and postoperative evaluation, ACTH, glucagon, and PGE2 increased postoperatively, while cortisol decreased. Glucagon and PG E2 were higher in group P than S, postoperatively
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
