Effects of Propofol on Arginine Vasopressin-induced Contraction in Isolated Human Gastroepiploic Artery

Abstract

Arginine vasopressin has been used by prophylactic treatment of vasodilatory shock during coronary artery bypass graft (CABG). Vasopressin may be a cause of spasm in graft artery during CABG. We evaluated the effect of propofol on vasopressin-induced contraction in human gastroepiploic artery (GEA). Methods: Human GEA were obtained from 35 patients (43−74 yr), undergoing subtotal gastrectomy. Vasopressin-induced a concentration contractions (10−9 to 10−6 M) were measured after exposed to without propofol, propofol 10−5, 10−4, 10−3 M. After endothelium denuding vasopressin-induced a concentration contractions were measured with or without propofol 10−3 M in calcium free solution. In the denuded vascular rings, with or without pretreatment of glibenclamide (10−5 M), nicorandil (10−5 M), or diltiazem (10−5 M) were exposed to with or without propofol 10−3 M, and vasopressin-induced concentration contractions were measured. Results: Vasopressin-induced concentration contraction on human GEA was independent of functional endothelium. Propofol (10−4, 10−3 M) attenuated the vasopressin-induced contraction in the human GEA. Diltiazem attenuated the vasopressin-induced contraction in the human GEA. ATP-sensitive potassium channel does not affect the inhibition effect of propofol on vasopressin-induced contraction Conclusions: Usual anesthetic dose of propofol does not inhibit vasopressin-induced contraction on human GEA. High dose (＞10−4 M) propofol attenuated vasopresssi-induced contraction on GEA.