Effects of propofol combined with sufentanil on prognostic VAS score and incidence of respiratory depression in ICU patients with mechanical ventilation

Abstract

Objective To investigate the effect of propofol combined with sufentanil on the prognostic visual analogue score (VAS) and the incidence of respiratory depression in patients in intensive care unit (ICU). Methods Seventy-one patients with mechanical ventilation in ICU were divided into two groups according to the random number table method; 35 patients in control group were given propofol for sedation and analgesia, 36 patients in observation group were given propofol combined with sufentanil for sedation and analgesia. The sedative effect and hemodynamics indexes [heart rate (HR) and mean arterial pressure (MAP)] were observed and compared between the two groups. The VAS scores, recovery situation after sedation, respiratory depression and incidence of hypotension were observed and compared between the two groups after weaning and extubation. Results The excellent and good rate of sedation was 91.67% (33/36) in observation group and was 88.57% (31/35) in control group, there was no significant difference between the two groups (P>0.05). At 10 min after administration and at extubation, HR and MAP of the two groups were higher than those before the administration, and the changes of observation group were smaller than those of control group (P 0.05). Conclusions Propofol combined with sufentanil is effective in the treatment of ICU patients with mechanical ventilation. It has good sedative effect and high safety, which can relieve the prognostic and pain of the patients, promote the recovery of the organism function after sedation, and have little influence on the hemodynamics. Key words: Propofol; Sufentanil; Mechanical ventilation; Visual analogue score; Respiratory depression